The Microsoft Natural Keyboard 4000 is pretty great, but the "Zoom" slider in the middle never seemed very useful to me - how often do I need to zoom in or out? I scroll much more often than I need to zoom, so it would be nice to remap to scroll instead. Although Microsoft's control panel lets you remap the special function keys, it doesn't let you change the Zoom slider function. Luckily for Windows users there's a fairly simple xml file that you can edit to change the mapping (and there are plenty of explanations: SuperUser , Josh Highland , Joel Bennett , etc). Unfortunately, the "commands.xml" config file doesn't exist on Mac OS X. Instead, there's a binary file for the configuration, which makes it tough to modify: /Users/YOUR_NAME/Library/Preferences/com.microsoft.keyboard.pref After a bit of reverse-engineering, I was able to remap the Zoom slider to the UP and DOWN keys (sadly, using the SCROLL mapping doesn't auto-repeat...